Cyno IL20&IL22&IL24 Triple Effector Reporter Cell
CBP74607
询 价
索取Protocol
产品描述
产品数据库
| I. Background | |
|
食蟹猴IL20、IL22和IL24均属于IL-10细胞因子家族，它们共享IL-22Rα1（即IL-22RA1）作为共同受体亚基，顺利获得形成不同受体复合物激活JAK-STAT信号通路。其中，IL20是一种促炎性细胞因子，在银屑病、类风湿关节炎等炎症性疾病中发挥重要作用；IL22主要参与组织修复和黏膜免疫，促进上皮细胞增殖并抵抗病原体感染；IL24因能诱导肿瘤细胞凋亡而被称为"黑色素瘤分化相关基因-7"，同时兼具抗血管生成功能。 |
|
| II. Description | |
|
Cyno IL20&IL22&IL24 Triple Effector Reporter Cell 报告基因药靶模型很好的模拟了体内 IL20&IL22&IL24 的信号转导过程。 |
|
| III. Introduction | |
| Expressed gene: | Cyno IL20&IL22&IL24 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin+200 μg/ml Hygromycin B+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Dose Response of Ligands in Cyno IL20&IL22&IL24 Triple Effector Reporter Cell(C30).  Figure 2. Inhibition of hIL20 Induced Reporter Activity by IL22Ra Blocking Ab or IL20 Neutralization Ab in Cyno IL20&IL22&IL24 Triple Effector Cell(C30).  Figure 3. Inhibition of Cyno IL22 Induced Reporter Activity by IL22Ra Blocking Ab or IL22 Neutralization Ab in Cyno IL20&IL22&IL24 Triple Effector Cell(C30).  Figure 4. Inhibition of hIL24 Induced Reporter Activity by IL22Ra Blocking Ab or IL24 Neutralization Ab in Cyno IL20&IL22&IL24 Triple Effector Cell (C30). |
|
|
|
|
